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Registro completo
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Biblioteca (s) : |
INIA Las Brujas. |
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Fecha : |
07/06/2022 |
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Actualizado : |
30/11/2022 |
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Tipo de producción científica : |
Artículos en Revistas Indexadas Internacionales |
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Autor : |
MACHADO, M.; CASTRO, M.B.; WILSON, T. M.; GONÇALVES , A. A. B.; PORTIANSKY, E.; RIET-CORREA, F.; BARROS, S. S. |
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Afiliación : |
MIZAEL MACHADO DA COSTA, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; MÁRCIO B. CASTRO, University of Brasilia, Brasília, Brazil; TAIS M. WILSON, University of Brasilia, Brasília, Brazil; ALEXANDRA A. B. GONÇALVES, University of Brasilia, Brasília, Brazil; ENRIQUE L. PORTIANSKY, National University of La Plata, La Plata, Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Argentina; FRANKLIN RIET-CORREA AMARAL, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; Federal University of Bahia, Salvador, Brazil; SEVERO S. BARROS, Federal University of Santa Maria, Rio Grande do Sul, Brazil. |
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Título : |
Poisoning by Nierembergia veitchii: Effects on vascular smooth muscle cells in the pathogenesis of enzootic calcinosis. |
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Fecha de publicación : |
2022 |
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Fuente / Imprenta : |
Veterinary Pathology, 2022, Volume 59, Issue 5, pages 814-823. doi: https://doi.org/10.1177/03009858221098430 |
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ISSN : |
0300-9858 |
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DOI : |
10.1177/03009858221098430 |
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Idioma : |
Inglés |
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Notas : |
Article history: Article first published online May 19, 2022; Published online September 2022. -- Corresponding Author: Franklin Riet-Correa, Postgraduate Program in Animal Science in the Tropics, School of Veterinary Medicine and Animal Science, Federal University of Bahia, Salvador, Bahia 40170-110, Brazil. Email: franklinrietcorrea@gmail.com -- This work was funded by National Institute of Agricultural Research (INIA) of Uruguay (Project CL 44), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, Brazil, (Finance Code 001) and National University of La Plata (Project V270). A postgraduate scholarship was provided to Mizael Machado by INIA, Uruguay. |
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Contenido : |
ABSTRACT - Vascular mineralization is a hallmark of enzootic calcinosis. Histopathological, ultrastructural, and immunohistochemical investigations were performed on the external carotid arteries of seven sheep naturally poisoned by Nierembergia veitchii. Histologically, moderate to marked hyperplasia of the tunica intima was observed without mineralization. The tunica media exhibited mild to severe mineralization and osteochondroid metaplasia. Sheep with enzootic calcinosis showed arterial overexpression of osteopontin and tissue-nonspecific alkaline phosphatase and immunolabeling for osteonectin and osteocalcin in both intima and media layers of the tested arteries. The main ultrastructural finding in the tunica media was a marked phenotypic change of vascular smooth muscle cells from a contractile phenotype (VSMC-C) into a synthetic phenotype (VSMC-S). In the tunica media, VSMC-S produced matrix and extracellular vesicles, forming mineralizable granules associated with arterial mineralization. VSMC-S were also present in the tunica intima, but matrix and extracellular vesicles and mineralization were not observed. The absence of matrix and extracellular vesicles in the intimal hyperplasia, even in the presence of noncollagenous bone proteins, tissue-nonspecific alkaline phosphatase, and vitamin D receptors, reinforces the hypothesis that the presence of matrix and extracellular vesicles are crucial for the development of vascular mineralization in enzootic calcinosis. It is proposed that the two different VSMC-S phenotypes in calcinosis are due to the expression of at least two genetically different types of these cells induced by the action of 1,25(OH)2D3. © The Author(s) 2022. MenosABSTRACT - Vascular mineralization is a hallmark of enzootic calcinosis. Histopathological, ultrastructural, and immunohistochemical investigations were performed on the external carotid arteries of seven sheep naturally poisoned by Nierembergia veitchii. Histologically, moderate to marked hyperplasia of the tunica intima was observed without mineralization. The tunica media exhibited mild to severe mineralization and osteochondroid metaplasia. Sheep with enzootic calcinosis showed arterial overexpression of osteopontin and tissue-nonspecific alkaline phosphatase and immunolabeling for osteonectin and osteocalcin in both intima and media layers of the tested arteries. The main ultrastructural finding in the tunica media was a marked phenotypic change of vascular smooth muscle cells from a contractile phenotype (VSMC-C) into a synthetic phenotype (VSMC-S). In the tunica media, VSMC-S produced matrix and extracellular vesicles, forming mineralizable granules associated with arterial mineralization. VSMC-S were also present in the tunica intima, but matrix and extracellular vesicles and mineralization were not observed. The absence of matrix and extracellular vesicles in the intimal hyperplasia, even in the presence of noncollagenous bone proteins, tissue-nonspecific alkaline phosphatase, and vitamin D receptors, reinforces the hypothesis that the presence of matrix and extracellular vesicles are crucial for the development of vascular mineralization in enzootic calcinosis. It ... Presentar Todo |
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Palabras claves : |
Arterial mineralization; Arteries; Enzootic calcinosis; Exosomes; Pathogenesis; PLATAFORMA DE SALUD ANIMAL; Toxicity; Vascular smooth muscle cells. |
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Asunto categoría : |
L50 Fisiología y bioquímica animal |
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Marc : |
LEADER 03391nam a2200313 a 4500
001 1063233
005 2022-11-30
008 2022 bl uuuu u01u1 u #d
022 $a0300-9858
024 7 $a10.1177/03009858221098430$2DOI
100 1 $aMACHADO, M.
245 $aPoisoning by Nierembergia veitchii$bEffects on vascular smooth muscle cells in the pathogenesis of enzootic calcinosis.$h[electronic resource]
260 $aVeterinary Pathology, 2022, Volume 59, Issue 5, pages 814-823. doi: https://doi.org/10.1177/03009858221098430$c1177
500 $aArticle history: Article first published online May 19, 2022; Published online September 2022. -- Corresponding Author: Franklin Riet-Correa, Postgraduate Program in Animal Science in the Tropics, School of Veterinary Medicine and Animal Science, Federal University of Bahia, Salvador, Bahia 40170-110, Brazil. Email: franklinrietcorrea@gmail.com -- This work was funded by National Institute of Agricultural Research (INIA) of Uruguay (Project CL 44), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, Brazil, (Finance Code 001) and National University of La Plata (Project V270). A postgraduate scholarship was provided to Mizael Machado by INIA, Uruguay.
520 $aABSTRACT - Vascular mineralization is a hallmark of enzootic calcinosis. Histopathological, ultrastructural, and immunohistochemical investigations were performed on the external carotid arteries of seven sheep naturally poisoned by Nierembergia veitchii. Histologically, moderate to marked hyperplasia of the tunica intima was observed without mineralization. The tunica media exhibited mild to severe mineralization and osteochondroid metaplasia. Sheep with enzootic calcinosis showed arterial overexpression of osteopontin and tissue-nonspecific alkaline phosphatase and immunolabeling for osteonectin and osteocalcin in both intima and media layers of the tested arteries. The main ultrastructural finding in the tunica media was a marked phenotypic change of vascular smooth muscle cells from a contractile phenotype (VSMC-C) into a synthetic phenotype (VSMC-S). In the tunica media, VSMC-S produced matrix and extracellular vesicles, forming mineralizable granules associated with arterial mineralization. VSMC-S were also present in the tunica intima, but matrix and extracellular vesicles and mineralization were not observed. The absence of matrix and extracellular vesicles in the intimal hyperplasia, even in the presence of noncollagenous bone proteins, tissue-nonspecific alkaline phosphatase, and vitamin D receptors, reinforces the hypothesis that the presence of matrix and extracellular vesicles are crucial for the development of vascular mineralization in enzootic calcinosis. It is proposed that the two different VSMC-S phenotypes in calcinosis are due to the expression of at least two genetically different types of these cells induced by the action of 1,25(OH)2D3. © The Author(s) 2022.
653 $aArterial mineralization
653 $aArteries
653 $aEnzootic calcinosis
653 $aExosomes
653 $aPathogenesis
653 $aPLATAFORMA DE SALUD ANIMAL
653 $aToxicity
653 $aVascular smooth muscle cells
700 1 $aCASTRO, M.B.
700 1 $aWILSON, T. M.
700 1 $aGONÇALVES , A. A. B.
700 1 $aPORTIANSKY, E.
700 1 $aRIET-CORREA, F.
700 1 $aBARROS, S. S.
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INIA Las Brujas (LB) |
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Registro completo
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Biblioteca (s) : |
INIA Las Brujas. |
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Fecha actual : |
26/02/2018 |
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Actualizado : |
26/02/2018 |
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Tipo de producción científica : |
Artículos en Revistas Indexadas Internacionales |
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Circulación / Nivel : |
Internacional - -- |
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Autor : |
LEONI, C.; BRUZZONE, J.; VILLAMIL, J.J.; MARTINEZ, C.; MONTELONGO, M.J.; BENTANCUR, O.; CONDE, P. |
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Afiliación : |
CAROLINA LEONI VELAZCO, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; JULIANA BRUZZONE PIZZORNO, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; JUAN JOSE VILLAMIL SILVA, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; ANA CECILIA MARTINEZ ESTEFAN, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; MARÍA JOSÉ MONTELONGO, Universidad de la República (UdelaR)/ Facultad de Agronomía; OSCAR BENTANCUR, Universidad de la República (UdelaR)/ Facultad de Agronomía; ANA PAULA CONDE INNAMORATO, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay. |
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Título : |
Percentage of anthracnose (Colletotrichum acutatum s.s.) acceptable in olives for the production of extra virgin olive oil. |
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Fecha de publicación : |
2018 |
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Fuente / Imprenta : |
Crop Protection, June 2018, v.108: 47-43. |
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DOI : |
10.1016/j.cropro.2018.02.013 |
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Idioma : |
Inglés |
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Notas : |
Article history: Received 15 February 2017; Revised 27 September 2017; Accepted 8 February 2018; Available online 22 February 2018.
Partial results were presented at 8th International Olive Symposium, Split, Croatia, 10?14 October 2016. |
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Contenido : |
Abstract
Anthracnose olive rot (AOR) is the main fruit disease of olives, causing direct yield losses and declining oil quality. Fruit infection occurs either in spring during flowering and fruit-set or in summer from the beginning of veraison to harvest. Conducive weather conditions (rain, elevated air relative humidity, air temperature above 20 °C) and the lack of effective chemical control strategies may compromise olive oil production. To quantify AOR effect on olive oil quality and to establish threshold levels, olive oil was extracted from olives with increasing disease incidence (from 0 to 30%), along three consecutive seasons (2012?2014) in two cultivars (cv. Arbeqina and cv. Frantoio) and disease severity index was also determined.
© 2018 Elsevier Ltd. All rights reserved. |
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Palabras claves : |
ARBEQUINA; FRANTOIO; OIL FREE ACIDITY; OLIVE OIL QUALITY; SOAPY OLIVE. |
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Thesagro : |
ACEITE OLIVA; CULTIVARES; OLEA EUROPAEA; OLIVOS; URUGUAY. |
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Asunto categoría : |
F01 Cultivo |
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Marc : |
LEADER 01969naa a2200337 a 4500
001 1058155
005 2018-02-26
008 2018 bl uuuu u00u1 u #d
024 7 $a10.1016/j.cropro.2018.02.013$2DOI
100 1 $aLEONI, C.
245 $aPercentage of anthracnose (Colletotrichum acutatum s.s.) acceptable in olives for the production of extra virgin olive oil.$h[electronic resource]
260 $c2018
500 $aArticle history: Received 15 February 2017; Revised 27 September 2017; Accepted 8 February 2018; Available online 22 February 2018. Partial results were presented at 8th International Olive Symposium, Split, Croatia, 10?14 October 2016.
520 $aAbstract Anthracnose olive rot (AOR) is the main fruit disease of olives, causing direct yield losses and declining oil quality. Fruit infection occurs either in spring during flowering and fruit-set or in summer from the beginning of veraison to harvest. Conducive weather conditions (rain, elevated air relative humidity, air temperature above 20 °C) and the lack of effective chemical control strategies may compromise olive oil production. To quantify AOR effect on olive oil quality and to establish threshold levels, olive oil was extracted from olives with increasing disease incidence (from 0 to 30%), along three consecutive seasons (2012?2014) in two cultivars (cv. Arbeqina and cv. Frantoio) and disease severity index was also determined. © 2018 Elsevier Ltd. All rights reserved.
650 $aACEITE OLIVA
650 $aCULTIVARES
650 $aOLEA EUROPAEA
650 $aOLIVOS
650 $aURUGUAY
653 $aARBEQUINA
653 $aFRANTOIO
653 $aOIL FREE ACIDITY
653 $aOLIVE OIL QUALITY
653 $aSOAPY OLIVE
700 1 $aBRUZZONE, J.
700 1 $aVILLAMIL, J.J.
700 1 $aMARTINEZ, C.
700 1 $aMONTELONGO, M.J.
700 1 $aBENTANCUR, O.
700 1 $aCONDE, P.
773 $tCrop Protection, June 2018$gv.108: 47-43.
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